Adding a certain compound to certain chemical reactions, such as: 918340-51-9, 4-Chlorofuro[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Chlorofuro[2,3-d]pyrimidine, blongs to pyrimidines compound. Safety of 4-Chlorofuro[2,3-d]pyrimidine
To a stirred solution of trans-4-(dimethylamino)cyclohexanol in freshly distilled THF (8 mL), cooled to 0C, was slowly added sodium hydride (40 mg, 1.00 mmol, 2.58 equiv, 60% dispersion in mineral oil) under nitrogen. The mixture was stirred at 0C for 30 min and then 4- chlorofuro[2,3-d]pyrimidine (60 mg, 0.39 mmol, 1.00 equiv) was added and the reaction was stirred overnight at 50C. The reaction solution was then quenched by the addition of water, extracted with ethyl acetate. The organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum. The crude product (80 mg) was purified by Prep-HPLC with the following conditions (SHIMADZU): Column, SunFire Prep CI 8, 19* 150mm 5um; mobile phase, water with 1% HCOOH and CH3CN (3.0% CH3CN up to 8.0% in 10 min); Flow rate: 20 mL/min; UV detection at 254/220 nm. The product-containing fractions were collected and partially evaporated to remove solvents under reduced pressure. The residue was lyophilized overnight to give the resulted tra/?5-4-(furo[2,3-d]pyrimidin-4-yloxy)-N,N- dimethylcyclohexanamine formate (37.3 mg, 31%) as a white solid. LCMS: (ES, m/z): 262 [M- HCOOH+H]+. 1H NMR: (400 MHz, CD3OD): delta 8.53 (1H, brs), 8.50 (1H, s), 7.84 (1H, d), 6.92 (1H, d), 5.37-5.31 (1H, m), 3.32-3.15 (1H, m), 2.74 (6H, s), 2.45 (2H, d), 2.20 (2H, d), 1.81-1.65 (4H, m).
The synthetic route of 918340-51-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NIMBUS IRIS, INC.; HARRIMAN, Geraldine C.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; WESSEL, Matthew David; GREENWOOD, Jeremy Robert; WO2014/11911; (2014); A2;,
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